The platform reports on genetic associations between genes and phenotypes. However, the effect size and orientation is important to contextualize results.
The cis-MR module allows for both effect size alignment and causal inference under the instrumental variable assumptions.
Plot of the effect of the PCs on the selected exposure and outcome. The red line shows the IVW estimate for the causal effect. Note that in the IVW estimator, the regression is weighted by the precision of the estimates and so PCs with smaller error bars are given a larger weight.
Small circles represent the effect of principal components that are excluded from the analysis because they are not associated with the exposure (to comply with the relevance assumption of MR).